Assessing the potential of online ICP–MS analysis to optimize Ca/matrix separation using DGA Resin for subsequent isotopic analysis

Abstract Ca isotopes have gained increasing interest as a diagnostic tool for bone diseases due to the variations in abundances consequence of changes bone-mineral balance. Optimized Ca/matrix separation prior analysis is prerequisite reliable isotope ratio measurements complex biological matrices such blood, serum, or urine. The online analyte/matrix by ICP-MS enables direct assessment elution profiles supporting optimization process. integration transient signals and signal suppression challenge quantification interpretation profiles. Mn Co remain unretained DGA Resin (TrisKem International) from nitric acid. Hence, present study, these elements were investigated their application standards monitor suppression. Successful analyte was accomplished using dynamic correction strategy applying linear gradient factor based on intensities. An optimized procedure proposed results during analysis. Graphic abstract